Article
Regulation of p53-mediated apoptosis and cell cycle arrest by Steel factor.
Molecular and cellular biology - 1 Dec 1995
Abrahamson J L, Lee J M, Bernstein A
Abstract excerpt
Activation of the p53 protein can lead to apoptosis and cell cycle arrest. In contrast, activation of the signalling pathway controlled by the Kit receptor tyrosine kinase prevents apoptosis and promotes cell division of a number of different cell types in vivo. We have investigated the consequences of activating the Kit signalling pathway by its ligand Steel factor on these opposing functions of the p53 protein...
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