Alterations in tumor development in vivo mediated by expression of wild type or mutant p53 proteins.

Abstract excerpt

To study the mechanism of p53 involvement in malignant transformation, we compared the tumor development patterns induced by a parental p53 nonproducer pre-B cell line with those by cell lines generated from this parental cell line following transfection of either wild type or mutant p53. It was found that whereas mutant p53 facilitated tumor development, expression of wild type p53 restrained tumor development....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blotting, Southern
• Share to Blotting, Western
• Share to Cell Differentiation