Alterations in tumor development in vivo mediated by expression of wild type or mutant p53 proteins.

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Article

Alterations in tumor development in vivo mediated by expression of wild type or mutant p53 proteins.

Cancer research - 1 Oct 1991

Shaulsky G, Goldfinger N, Rotter V

Abstract excerpt

To study the mechanism of p53 involvement in malignant transformation, we compared the tumor development patterns induced by a parental p53 nonproducer pre-B cell line with those by cell lines generated from this parental cell line following transfection of either wild type or mutant p53. It was...

Topics

Animals
Blotting, Southern
Blotting, Western
Cell Differentiation
Cell Transformation, Neoplastic
DNA
Epitopes
Genes, p53
Immunoglobulin G
Male
Mice
Mice, Inbred Strains
Mutation
Neoplasm Transplantation
Transfection
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 1717142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1717142-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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