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Article

p53 gene mutation spectrum in human unknown primary tumors.

Anticancer research - 1 Jan 2000

Bar-Eli M, Abbruzzese J L, Lee-Jackson D, Frost P

Abstract excerpt

Mutations affecting the p53 gene are associated with many human malignancies, but little is known about changes in p53 in unknown primary tumors (UPTs), which are characterized as tumors with advanced stages of malignancy. We therefore investigated the frequency of p53 mutations in a series of 15 unknown primary tumor biopsies and eight cell lines established from UPTs. Mutations in the conserved regions of the...

Topics

Amino Acid Sequence
Codon
Genes, p53
Humans
Molecular Sequence Data
Mutation
Neoplasm Metastasis
Neoplasms, Unknown Primary
Prognosis
Tumor Cells, Cultured

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PMID: 8239543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8239543-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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