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Article

p53 mutations in primary human lung tumors and their metastases.

Molecular carcinogenesis - 1 Feb 1994

Reichel M B, Ohgaki H, Petersen I, Kleihues P

Abstract excerpt

In a total of 26 primary human lung tumors and 60 metastases derived from them, exons 5-8 of the p53 tumor suppressor gene were analyzed by single-strand conformation polymorphism and subsequent direct DNA sequencing of amplified DNA. Mutational inactivation of the p53 gene was identified in four of five squamous cell carcinomas, three of nine adenocarcinomas, and two of nine small-cell carcinomas, the overall...

Topics

Aged
Aged, 80 and over
Base Sequence
Codon
Exons
Female
Genes, p53
Humans
Lung Neoplasms
Male
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Metastasis

Source

Identifiers

PMID: 8142008
DOI: 10.1002/mc.2940090208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8142008-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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