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Article

Mutated p53 in HGSC—From a Common Mutation to a Target for Therapy

10 Jul 2021

Abstract excerpt

Mutations in tumor suppressor gene TP53, encoding for the p53 protein, are the most ubiquitous genetic variation in human ovarian HGSC, the most prevalent and lethal histologic subtype of epithelial ovarian cancer (EOC). The majority of TP53 mutations are missense mutations, leading to loss of tumor suppressive function of p53 and gain of new oncogenic functions. This review presents the clinical relevance of...

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PMID: 34298679
DOI: 10.3390/cancers13143465

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