Article
New mutations in the human p53 gene--a regulator of the cell cycle and carcinogenesis.
Biochemistry. Biokhimiia - 1 Mar 2007
Kashkin K N, Khlgatian S V, Gurova O V, Kuprash D V, Nedospasov S A
Abstract excerpt
Mutations in the tumor suppressor gene p53 often lead to disarrangement of the cell cycle and of genetic integrity control of cells that may contribute to tumor development. We studied p53 gene mutations in 26 primary tumors of colorectal cancer patients. Mutations in p53 were found in 17 tumors (65.4%). All point mutations affected the DNA binding domain of p53 and were localized in exons 4-8 of the gene. Mutant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.