Article
p53 gene mutation in primary human renal cell carcinoma.
Oncology research - 1 Jan 1992
Torigoe S, Shuin T, Kubota Y, Horikoshi T, Danenberg K, Danenberg P V
Abstract excerpt
We searched for possible mutations in the entire coding region of tumor suppressor gene p53 in primary human renal cell carcinomas using polymerase chain reaction and single-strand conformational polymorphism analysis of RNA. We found p53 mutations in 2 of 21 cases (10%). DNA sequencing of the polymerase chain reaction products verified that the first case included a 17-base deletion at the beginning of exon 6....
Topics
- Base Sequence
- Carcinoma, Renal Cell
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Tumor Suppressor Protein p53