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Article

Altered messenger RNA and unique mutational profiles of p53 and Rb in human esophageal carcinomas.

Cancer research - 15 Apr 1993

Huang Y, Meltzer S J, Yin J, Tong Y, Chang E H, Srivastava S, McDaniel T, Boynton R F, Zou Z Q

Abstract excerpt

Seventy-nine esophageal carcinoma patients were studied for genetic abnormalities in the p53 and Rb tumor suppressor genes. Single-strand conformation polymorphism analysis and DNA sequencing were used to detect p53 point mutations, Northern blotting was used to examine abnormal expression of p53 and Rb, and polymerase chain reaction and Southern blotting were used to analyze allelic loss. Twenty-five cases were...

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PMID: 8467510

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