Article
Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.
Oncogene - 1 Oct 1990
Chiba I, Takahashi T, Nau M M, D'Amico D, Curiel D T, Mitsudomi T, Buchhagen D L, Carbone D, Piantadosi S, Koga H
Abstract excerpt
The p53 gene has been implicated as a tumor suppressor gene with mutations found in common human cancers. We examined 51 early stage, primary, resected non-small cell lung cancer specimens using an RNAase protection assay and cDNA sequencing. Mutations changing the p53 coding sequence were found...
Topics
- Aged
- Base Sequence
- Biological Evolution
- Carcinoma, Non-Small-Cell Lung
- Codon
- DNA, Neoplasm
- Exons
- Female
- Genes, Suppressor
- Humans
- Introns
- Lung Neoplasms
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymerase Chain Reaction