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Article

p53 mutations in human cancers.

Science (New York, N.Y.) - 5 Jul 1991

Hollstein M, Sidransky D, Vogelstein B, Harris C C

Abstract excerpt

Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are common in diverse types of human cancer. The p53 mutational spectrum differs among cancers of the colon, lung, esophagus, breast, liver, brain, reticuloendothelial tissues, and hemopoietic tissues. Analysis of these mutations can provide clues to the etiology of these diverse tumors and to the function of specific regions of...

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Identifiers

PMID: 1905840
DOI: 10.1126/science.1905840

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Source receipt: pubmed, retrieved 7 Sept 2026.

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