Article
p53 mutations in human cancers.
Science (New York, N.Y.) - 5 Jul 1991
Hollstein M, Sidransky D, Vogelstein B, Harris C C
Abstract excerpt
Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are common in diverse types of human cancer. The p53 mutational spectrum differs among cancers of the colon, lung, esophagus, breast, liver, brain, reticuloendothelial tissues, and hemopoietic tissues. Analysis of t...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chickens
- DNA Mutational Analysis
- Genes, p53
- Haplorhini
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Neoplasms
- Rats
- Sequence Homology, Nucleic Acid
- Trout
- Xenopus