Article

Mutations in TP53 and other heterogeneous genes help to distinguish metastases from new primary malignancies

2020-11-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Distinguishing metastases from new primary malignancies or vice versa is important because misclassification can result in inappropriate management. However, for some cases this distinction can be challenging, particularly for squamous cell carcinomas in which the usual surgical pathology approach, predominantly morphology and immunohistochemistry, are frequently non-contribut...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e05c77f-0b77-5d64-904f-2b6eb478e216
DOI: 10.1101/2020.11.11.20226845

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutations in TP53 and other heterogeneous genes help to distinguish metastases from new primary malignanciesDOI 10.1101/2020.11.11.20226845Read

Four Metachronous Cancers: Mutation Profiling Can Be Used to Distinguish Multiple Primary Cancers from Metastases.Semantic proximity Read

TP53 Mutations as a Driver of Metastasis Signaling in Advanced Cancer PatientsSemantic proximity Read

TP53 mutations as potential prognostic markers for specific cancers: Analysis of data from The Cancer Genome Atlas and the International Agency for Research on Cancer TP53 DatabaseSemantic proximity Read

Tumor-Origin.com: A Machine Learning Platform for Predicting Tumor Tissue of Origin from Somatic Mutation ProfilesSemantic proximity Read

Establishing the origin of metastatic deposits in the setting of multiple primary malignancies: the role of massively parallel sequencing.Semantic proximity Read

Using molecular characteristics to distinguish multiple primary lung cancers and intrapulmonary metastases.Semantic proximity Read

TumorTracer: a method to identify the tissue of origin from the somatic mutations of a tumor specimen.Semantic proximity Read

Mutational Landscape of TP53 Across Cancer TypesSemantic proximity Read

Cancer beyond organ and tissue specificity: next-generation-sequencing gene mutation data reveal complex genetic similarities across major cancers.Semantic proximity Read

Cancer of Unknown Primary (CUP): genetic evidence for a novel nosological entity? A case report.Semantic proximity Read

Co-evolution of somatic variation in primary and metastatic colorectal cancer may expand biopsy indications in the molecular era.Semantic proximity Read

Clinical Outcomes of TP53 Mutations in Cancers.Semantic proximity Read