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Article

Analysis of 4-nitroquinoline-1-oxide induced mutations at the hprt locus in mammalian cells: possible involvement of preferential DNA repair.

Mutagenesis - 1 Jan 1994

Inga A, Iannone R, Degan P, Campomenosi P, Fronza G, Abbondandolo A, Menichini P

Abstract excerpt

Mutation spectra induced by 4-nitroquinoline 1-oxide (4NQO) at the hprt locus for both normal (AA8) and 4NQO-sensitive (UV5) Chinese hamster ovary cells were determined to investigate the effect of DNA repair on the nature of induced mutations. The UV5 cell line is three times more sensitive to 4NQO than the AA8 parental cell line. In UV5 cells, the dGuo-N2-AQO adduct, which is considered to be the most toxic and...

Topics

4-Nitroquinoline-1-oxide
Animals
Base Sequence
CHO Cells
Cell Survival
Cricetinae
DNA Primers
DNA Repair
DNA, Complementary
Hypoxanthine Phosphoribosyltransferase
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Point Mutation

RNA Splicing

Source

Identifiers

PMID: 8208132
DOI: 10.1093/mutage/9.1.67

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8208132-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Analysis of 4-nitroquinoline-1-oxide induced mutations at the hprt locus in mammalian cells: possible involvement of preferential DNA repair.PMID 8208132Read ↗

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