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Molecular characterization of hprt mutations from Chinese hamster ovary cells treated with 1-, 3-, and 6-nitrosobenzo[a]pyrene.

Environmental and molecular mutagenesis - 1 Jan 1998

Zhan D J, Chiu L H, Heflich R H, Fu P P

Abstract excerpt

1-, 3-, and 6-nitrobenzo[a]pyrene (nitro-BaP) are environmental contaminants that can be metabolized to genotoxic derivatives by either nitroreduction or ring-oxidation. In this study, we examined the types of mutations produced by the primary nitroreduced metabolites, 1-, 3-, and 6-nitroso-BaP (NO-BaP) in the hprt gene of Chinese hamster ovary cells. RNA from 6-thioguanine-resistant mutants was...

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PMID: 9464317
DOI: 10.1002/(sici)1098-2280(1998)31:1<60::aid-em9>3.0.co;2-f

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