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Molecular analysis of DNA adducts and hprt mutations produced by 6-nitrosochrysene in Chinese hamster ovary cells.

Carcinogenesis - 1 Sept 1993

Manjanatha M G, Newton R K, Mittelstaedt R A, Villani G R, Declos K B, Heflich R H

Abstract excerpt

We have characterized the mutational spectrum of 6-nitrosochrysene in the hprt gene of Chinese hamster ovary (CHO-K1) cells and also examined the adducts formed by this compound in CHO-K1 cells by quantitative 32P-postlabeling analysis. Seventy percent of the identified mutations were simple basepair substitutions, and they occurred more often at A:T (14/17) than at G:C. Furthermore, 13 of the basepair...

Topics

Animals
Base Composition
CHO Cells
Chrysenes
Cricetinae
DNA
DNA Mutational Analysis
DNA, Complementary
Mutation
Tetrahydrofolate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 8403211
DOI: 10.1093/carcin/14.9.1863

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