Article

An AOP-informed testing strategy to identify chemicals causing genotoxicity through oxidative DNA damage: case study on 4-nitroquinoline 1-oxide

2024-12-16

Abstract excerpt

Adverse outcome pathways (AOPs) provide a framework to organize and weigh evidence linking molecular interactions of toxicants in cells to outcomes of regulatory concern. Applying this framework facilitates the interpretation of data produced using new test methods. We used AOP #296 which describes how oxidative DNA damage leads to mutations and chromosomal aberrations to develop an integrated testing strategy to...

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Literature Corpus work: 2978b4ab-1355-58e0-b490-29658ce16406
DOI: 10.22541/au.173438285.52591085/v1

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