Article
Adverse Outcome Pathway-Informed Integrated Testing to Identify Chemicals Causing Genotoxicity Through Oxidative DNA Damage: Case Study on 4-Nitroquinoline 1-Oxide.
Environmental and molecular mutagenesis - 1 Apr 2025
Huliganga Elizabeth, Cho Eunnara, Swartz Carol D, Williams Andrew, Recio Leslie, Salk Jesse J, Marchetti Francesco, Yauk Carole L
Abstract excerpt
Adverse outcome pathways (AOPs) provide a framework to organize and weigh evidence linking molecular interactions of toxicants in cells to adverse outcomes relevant to risk assessment or regulatory decision-making. Applying this framework facilitates the interpretation of data produced using new...
Topics
- 4-Nitroquinoline-1-oxide
- Humans
- DNA Damage
- Oxidative Stress
- Mutagens
- Mutagenicity Tests
- Adverse Outcome Pathways
- Mutation
- Micronucleus Tests
- Comet Assay
- Cell Line