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Adverse Outcome Pathway-Informed Integrated Testing to Identify Chemicals Causing Genotoxicity Through Oxidative DNA Damage: Case Study on 4-Nitroquinoline 1-Oxide.

Environmental and molecular mutagenesis - 1 Apr 2025

Huliganga Elizabeth, Cho Eunnara, Swartz Carol D, Williams Andrew, Recio Leslie, Salk Jesse J, Marchetti Francesco, Yauk Carole L

Abstract excerpt

Adverse outcome pathways (AOPs) provide a framework to organize and weigh evidence linking molecular interactions of toxicants in cells to adverse outcomes relevant to risk assessment or regulatory decision-making. Applying this framework facilitates the interpretation of data produced using new test methods. We used an existing AOP (AOP #296) that describes how oxidative DNA damage leads to mutations and...

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Identifiers

PMID: 40341686
DOI: 10.1002/em.70011
PMCID: PMC12087725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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