The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency.

doi:10.1093/mutage/gev069

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Article

The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency.

Mutagenesis - 1 Mar 2016

Brüsehafer Katja, Manshian Bella B, Doherty Ann T, Zaïr Zoulikha M, Johnson George E, Doak Shareen H, Jenkins Gareth J S

Abstract excerpt

4-Nitroquinoline 1-oxide (4NQO) is used as a positive control in various genotoxicity assays because of its known mutagenic and carcinogenic properties. The chemical is converted into 4-hydroxyaminoquinoline 1-oxide and gives rise to three main DNA adducts, N-(deoxyguanosin-8-yl)-4AQO, 3-(desoxyguanosin-N (2)-yl)-4AQO and 3-(deoxyadenosin-N (6)-yl)-4AQO. This study was designed to assess the shape of the...

Topics

4-Nitroquinoline-1-oxide
Animals
Carcinogens
Cell Line, Tumor
Chromosome Aberrations
Comet Assay
DNA Damage
Dose-Response Relationship, Drug
Humans
Hypoxanthine Phosphoribosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Micronucleus Tests

Mutagenicity Tests

Mutagens

Mutation

Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 26362870
DOI: 10.1093/mutage/gev069
PMCID: PMC4748179

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