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Article

Specificity of mutations induced by N-methyl-N-nitrosourea in a cDNA of the hprt gene.

Carcinogenesis - 1 Apr 1993

Akagi T, Hiromatsu K, Iyehara-Ogawa H, Kimura H, Kato T

Abstract excerpt

N-Methyl-N-nitrosourea (MNU) reacts with DNA to produce a variety of lesions, of which O6-methylguanine (O6-MeG) has been implicated in the mutagenic and carcinogenic effects of this agent. The present study aimed to investigate the types and position specificities of mutations induced by MNU. Mutational sequence alterations were determined for 53 independent mutations induced by MNU in a cDNA of the human hprt...

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PMID: 8472339
DOI: 10.1093/carcin/14.4.725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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