Article
Strand-specific mutation spectra in repair-proficient and repair-deficient hamster cells.
Mutation research - 1 Nov 1991
Menichini P, Vrieling H, van Zeeland A A
Abstract excerpt
The mutation spectrum induced by UV light has been determined at the hprt locus for both cultured normal (AA8) and UV-sensitive (UV-5) Chinese hamster ovary cells to investigate the effect of DNA repair on the nature of induced mutations. DNA base-pair changes of 23 hprt mutants of AA8 and of 28 hprt mutants of UV-5 were determined by sequence analysis of in vitro amplified hprt cDNA. Almost all mutants in AA8...
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