Article
The repair of 4-nitroquinoline-1-oxide induced DNA adducts in hypersensitive Chinese hamster mutants: lack of repair of UV induced (6-4) photoproduct correlates with reduced repair of adducts at the N2 of guanosine.
Mutagenesis - 1 Nov 1991
Yang A L, Zdzienicka M Z, Simons J W, Waters R
Abstract excerpt
UV sensitive Chinese hamster mutants belonging to ERCC groups 1, 2 and 6 together with one cross-link- and one X-ray-sensitive mutant have been examined for sensitivity to 4-nitroquinoline-1-oxide (4NQO) and the ability to repair 4NQO adducts at the N2 and C8 of guanosine. Despite the fact that all of the mutants examined were hyper-sensitive to 4NQO there was little difference between the mutants V-H1, V-H4,...
Topics
- 4-Nitroquinoline-1-oxide
- Animals
- Cell Death
- Cell Line
- Cricetinae
- DNA
- DNA Repair
- Guanosine
- Mutation
- Ultraviolet Rays