Article
Hereditary nonpolyposis colon cancer: analysis of linkage to 2p15-16 places the COCA1 locus telomeric to D2S123 and reveals genetic heterogeneity in seven Canadian families.
American journal of human genetics - 1 Jun 1994
Green R C, Narod S A, Morasse J, Young T L, Cox J, Fitzgerald G W, Tonin P, Ginsburg O, Miller S, Jothy S
Abstract excerpt
Hereditary nonpolyposis colon cancer (HNPCC) is an autosomal dominant trait responsible for approximately 6% of colorectal cancers. Linkage of the HNPCC trait to the D2S123 locus on 2p15-16 has previously been reported in two families. This HNPCC locus is now designated "COCA1." We have tested seven Canadian HNPCC families, who have a variety of clinical presentations, for linkage to a panel of microsatellite...
Topics
- Adenomatous Polyps
- Adult
- Aged
- Alleles
- Canada
- Chromosome Mapping
- Chromosomes, Human, Pair 2
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Female
- Genetic Linkage