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Article

Chromosome 2p linkage analysis in hereditary non-polyposis colon cancer.

Journal of gastroenterology and hepatology - 1 Jan 2000

Kohonen-Corish M R, Doe W F, St John D J, Macrae F A

Abstract excerpt

Hereditary non-polyposis colon cancer (HNPCC) comprises 2-6% of the total colorectal cancer burden. Two families are described that show linkage between the HNPCC susceptibility gene and the markers D2S123 and D2S119 on chromosome 2p, producing multipoint lod scores of 3.62 and 3.83, respectively, in the largest pedigree. In our third family the multipoint lod scores for D2S123 and D2S119, -2.97 and -3.12,...

Topics

Chromosomes, Human, Pair 2
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA, Neoplasm
DNA, Satellite
Female
Genetic Linkage
Genetic Markers
Humans
Male
Middle Aged
Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7620112
DOI: 10.1111/j.1440-1746.1995.tb01052.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7620112-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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