Article
The use of DNA markers in the pre-clinical diagnosis of familial adenomatous polyposis.
Israel journal of medical sciences - 1 Jan 1997
Amikam D, Niv D, Lachter J, Eidelman S, Ben-Ishai Z
Abstract excerpt
Familial adenomatous polyposis (FAP), an autosomal dominant inherited disease, confers a high risk of colon cancer. For presymptomatic diagnosis of FAP, we performed linkage studies in three unrelated Israeli families with FAP, using seven polymorphic systems around or at the APC locus on chromos...
Topics
- Adenine
- Adenomatous Polyposis Coli
- Alleles
- Biomarkers, Tumor
- Chromosomes, Human, Pair 5
- Cytosine
- DNA Probes
- Dinucleotide Repeats
- Female
- Genetic Linkage
- Haplotypes
- Humans
- Israel
- Male
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length