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Article

Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer.

Nature genetics - 1 Nov 1993

Lindblom A, Tannergård P, Werelius B, Nordenskjöld M

Abstract excerpt

Hereditary colon cancer is caused by mutations in several different loci. The APC gene on chromosome 5 causing adenomatous polyposis coli represents a minority of the inherited colon cancer cases, while hereditary-non polyposis colon cancer (HNPCC) may cause five percent of all human colon cancer. One gene causing HNPCC was recently mapped to chromosome 2 but the same study also showed that at least one...

Topics

Chromosome Mapping
Chromosomes, Human, Pair 3
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA, Satellite
Female
Genetic Linkage
Genetic Predisposition to Disease
Humans
Male
Mutation
Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 7903889
DOI: 10.1038/ng1193-279

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7903889-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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