Article
Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage.
American journal of human genetics - 1 Oct 1994
Nyström-Lahti M, Parsons R, Sistonen P, Pylkkänen L, Aaltonen L A, Leach F S, Hamilton S R, Watson P, Bronson E, Fusaro R
Abstract excerpt
Two susceptibility loci for hereditary nonpolyposis colorectal cancer (HNPCC) have been identified, and each contains a mismatch repair gene: MSH2 on chromosome 2p and MLH1 on chromosome 3p. We studied the involvement of these loci in 13 large HNPCC kindreds originating from three different conti...
Topics
- Adult
- Chromosome Mapping
- Chromosomes, Human, Pair 2
- Chromosomes, Human, Pair 3
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Repair
- DNA, Satellite
- Female
- Genetic Linkage
- Genetic Markers
- Humans
- Lod Score
- Male
- Middle Aged