Article
Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage.
American journal of human genetics - 1 Oct 1994
Nyström-Lahti M, Parsons R, Sistonen P, Pylkkänen L, Aaltonen L A, Leach F S, Hamilton S R, Watson P, Bronson E, Fusaro R
Abstract excerpt
Two susceptibility loci for hereditary nonpolyposis colorectal cancer (HNPCC) have been identified, and each contains a mismatch repair gene: MSH2 on chromosome 2p and MLH1 on chromosome 3p. We studied the involvement of these loci in 13 large HNPCC kindreds originating from three different continents. Six families showed close linkage to the 2p locus, and a heritable mutation of the MSH2 gene was subsequently...
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