Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22.

doi:10.1371/journal.pone.0038175

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Article

Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22.

PloS one - 1 Jan 2012

Cicek Mine S, Cunningham Julie M, Fridley Brooke L, Serie Daniel J, Bamlet William R, Diergaarde Brenda, Haile Robert W, Le Marchand Loic, Krontiris Theodore G, Younghusband H Banfield, Gallinger Steven, Newcomb Polly A, Hopper John L, Jenkins Mark A, Casey Graham, Schumacher Fredrick, Chen Zhu, DeRycke Melissa S, Templeton Allyson S, Winship Ingrid, Green Roger C, Green Jane S, Macrae Finlay A, Parry Susan, Young Graeme P, Young Joanne P, Buchanan Daniel, Thomas Duncan C, Bishop D Timothy, Lindor Noralane M, Thibodeau Stephen N, Potter John D, Goode Ellen L

Abstract excerpt

A substantial proportion of familial colorectal cancer (CRC) is not a consequence of known susceptibility loci, such as mismatch repair (MMR) genes, supporting the existence of additional loci. To identify novel CRC loci, we conducted a genome-wide linkage scan in 356 white families with no evidence of defective MMR (i.e., no loss of tumor expression of MMR proteins, no microsatellite instability (MSI)-high...

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PMID: 22675446
DOI: 10.1371/journal.pone.0038175
PMCID: PMC3364975

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