Genome-wide linkage scan for colorectal cancer susceptibility genes supports linkage to chromosome 3q.

doi:10.1186/1471-2407-8-87

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Article

Genome-wide linkage scan for colorectal cancer susceptibility genes supports linkage to chromosome 3q.

BMC cancer - 1 Apr 2008

Picelli Simone, Vandrovcova Jana, Jones Siân, Djureinovic Tatjana, Skoglund Johanna, Zhou Xiao-Lei, Velculescu Victor E, Vogelstein Bert, Lindblom Annika

Abstract excerpt

BACKGROUND: Colorectal cancer is one of the most common causes of cancer-related mortality. The disease is clinically and genetically heterogeneous though a strong hereditary component has been identified. However, only a small proportion of the inherited susceptibility can be ascribed to dominant syndromes, such as Hereditary Non-Polyposis Colorectal Cancer (HNPCC) or Familial Adenomatous Polyposis (FAP). In an...

Topics

Aged
Chromosomes, Human, Pair 3
Colorectal Neoplasms
Female
Genetic Linkage
Genetic Predisposition to Disease
Genome
Humans
Male
Middle Aged
Sweden

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PMID: 18380902
DOI: 10.1186/1471-2407-8-87
PMCID: PMC2324103

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