Article
Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 1994
Nyström-Lahti M, Sistonen P, Mecklin J P, Pylkkänen L, Aaltonen L A, Järvinen H, Weissenbach J, de la Chapelle A, Peltomäki P
Abstract excerpt
A susceptibility to hereditary nonpolyposis colorectal cancer (HNPCC) was recently shown to be due to mutations in the MSH2 gene on chromosome 2p. A second susceptibility locus has been mapped to chromosome 3p in two families. The present report describes the results of a genetic study of Finnish HNPCC kindreds. Of 18 apparently unrelated families living in different parts of the country, 11 could be...
Topics
- Adenoma
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 3
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA, Satellite
- Female
- Finland
- Genetic Linkage
- Genetic Markers