Article
Genetic linkage analysis in hereditary non-polyposis colon cancer syndrome.
Journal of medical genetics - 1 May 1995
Froggatt N J, Koch J, Davies R, Evans D G, Clamp A, Quarrell O W, Weissenbach J, Hodgson S V, Ponder B A, Barton D E
Abstract excerpt
Hereditary Non-polyposis Colon Cancer Syndrome (HNPCC) is the most common cause of familial colorectal cancer. Molecular genetic studies of HNPCC have shown evidence of locus heterogeneity, and mutations in four genes (hMSH2, hMLH1, hPMS1, and hPMS2) which encode components of the mismatch enzyme repair system may cause HNPCC. To determine the extent and nature of locus heterogeneity in HNPCC, we performed...
Topics
- Adaptor Proteins, Signal Transducing
- Adenosine Triphosphatases
- Adult
- Carrier Proteins
- Chromosome Mapping
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Repair Enzymes
- DNA-Binding Proteins
- England
- Female