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Genetic analysis of colon cancer susceptibility in mice.

Genomics - 15 Jul 1994

Jacoby R F, Hohman C, Marshall D J, Frick T J, Schlack S, Broda M, Smutko J, Elliott R W

Abstract excerpt

Mouse models may aid in the identification of genes involved in colon cancer. Our mating scheme involved mouse strains selected for maximum differences in susceptibility to DMH-induced colon tumors. Tumors were found in 40 of 122 progeny from a backcross to the resistant strain. We examined progeny animals for segregation of 177 genetic markers distributed at intervals of 5-30 cM on all mouse chromosomes....

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PMID: 7806225
DOI: 10.1006/geno.1994.1399

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FOS

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Source receipt: pubmed, retrieved 7 Sept 2026.

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