Genetic analysis of colon cancer susceptibility in mice.

doi:10.1006/geno.1994.1399

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Article

Genetic analysis of colon cancer susceptibility in mice.

Genomics - 15 Jul 1994

Jacoby R F, Hohman C, Marshall D J, Frick T J, Schlack S, Broda M, Smutko J, Elliott R W

Abstract excerpt

Mouse models may aid in the identification of genes involved in colon cancer. Our mating scheme involved mouse strains selected for maximum differences in susceptibility to DMH-induced colon tumors. Tumors were found in 40 of 122 progeny from a backcross to the resistant strain. We examined progeny animals for segregation of 177 genetic markers distributed at intervals of 5-30 cM on all mouse chromosomes....

Topics

1,2-Dimethylhydrazine
Animals
Base Sequence
Colonic Neoplasms
Crosses, Genetic
Dimethylhydrazines
Disease Models, Animal
Disease Progression
Genetic Markers
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lod Score

Mice

Mice, Inbred C57BL

Mice, Inbred ICR

Molecular Sequence Data

Polymerase Chain Reaction

Sequence Homology, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 7806225
DOI: 10.1006/geno.1994.1399

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7806225-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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