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Article

Genetic heterogeneity and unmapped genes for colorectal cancer.

Cancer research - 15 Mar 1996

Lewis C M, Neuhausen S L, Daley D, Black F J, Swensen J, Burt R W, Cannon-Albright L A, Skolnick M H

Abstract excerpt

Colorectal cancer (CRC) has a strong familial component. Candidate genes for colorectal cancer have been identified through mutations in four mismatch repair genes (hMSH2, hMLH1, hPMS1, and hPMS2) and genes that are deleted or mutated in tumors (DCC, APC, and p53). Linkage analysis of candidate loci/regions was performed in 10 kindreds ascertained for common colorectal cancer from the Utah Population Database....

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PMID: 8640829

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DCC

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