Genetic heterogeneity and unmapped genes for colorectal cancer.

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Article

Genetic heterogeneity and unmapped genes for colorectal cancer.

Cancer research - 15 Mar 1996

Lewis C M, Neuhausen S L, Daley D, Black F J, Swensen J, Burt R W, Cannon-Albright L A, Skolnick M H

Abstract excerpt

Colorectal cancer (CRC) has a strong familial component. Candidate genes for colorectal cancer have been identified through mutations in four mismatch repair genes (hMSH2, hMLH1, hPMS1, and hPMS2) and genes that are deleted or mutated in tumors (DCC, APC, and p53). Linkage analysis of candidate l...

Topics

Adult
Age of Onset
Aged
Aged, 80 and over
Chromosome Mapping
Colorectal Neoplasms
DNA-Binding Proteins
Disease Susceptibility
Family
Female
Genetic Heterogeneity
Genetic Linkage
Genetic Markers
Humans
Lod Score
Male
Middle Aged
Mutation

Source

Open in PubMed

Identifiers

PMID: 8640829

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8640829-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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