Article
Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis.
Cancer research - 1 Jun 1994
Miyake S, Nagai K, Yoshino K, Oto M, Endo M, Yuasa Y
Abstract excerpt
Since tumor suppressor gene DCC exhibits amino acid sequence homology to the neural cell adhesion molecule, there is a possibility that DCC might be related to tumor metastasis. In the present study, we examined 51 cases of primary esophageal carcinomas with regard to point mutations and loss of the DCC gene. We detected point mutations in two cases by screening using polymerase chain reaction-single strand...
Topics
- Alleles
- Base Sequence
- Carcinoma, Squamous Cell
- Esophageal Neoplasms
- Gene Deletion
- Genes, DCC
- Humans
- Molecular Sequence Data
- Neoplasm Metastasis
- Point Mutation
- Polymerase Chain Reaction