Article
Expression and mutational analysis of the DCC, DPC4, and MADR2/JV18-1 genes in neuroblastoma.
Cancer research - 1 Sept 1997
Kong X T, Choi S H, Inoue A, Xu F, Chen T, Takita J, Yokota J, Bessho F, Yanagisawa M, Hanada R, Yamamoto K, Hayashi Y
Abstract excerpt
Loss of heterozygosity (LOH) on chromosome 18q21 is found frequently in various human cancers. Three candidate tumor suppressor genes, DCC (deleted in colorectal carcinomas), DPC4 (deleted in pancreatic carcinomas, locus 4), and MADR2/JV18-1 (MAD-related gene 2), have been cloned and identified f...
Topics
- Cell Adhesion Molecules
- Child
- Child, Preschool
- DCC Receptor
- DNA-Binding Proteins
- Exons
- Female
- Gene Expression
- Genes, DCC
- Genes, Tumor Suppressor
- Humans
- Infant
- Infant, Newborn
- Male
- Mutation
- Neoplasm Proteins
- Neoplasm Staging
- Neuroblastoma
