Article
Identification of a chromosome 18q gene that is altered in colorectal cancers.
Science (New York, N.Y.) - 5 Jan 1990
Fearon E R, Cho K R, Nigro J M, Kern S E, Simons J W, Ruppert J M, Hamilton S R, Preisinger A C, Thomas G, Kinzler K W
Abstract excerpt
Allelic deletions involving chromosome 18q occur in more than 70 percent of colorectal cancers. Such deletions are thought to signal the existence of a tumor suppressor gene in the affected region, but until now a candidate suppressor gene on this chromosomal arm had not been identified. A contiguous stretch of DNA comprising 370 kilobase pairs (kb) has now been cloned from a region of chromosome 18q suspected to...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Cell Adhesion Molecules, Neuronal
- Chromosome Deletion
- Chromosomes, Human, Pair 18
- Cloning, Molecular