Article
The DCC gene: structural analysis and mutations in colorectal carcinomas.
Genomics - 1 Feb 1994
Cho K R, Oliner J D, Simons J W, Hedrick L, Fearon E R, Preisinger A C, Hedge P, Silverman G A, Vogelstein B
Abstract excerpt
DCC is a candidate tumor-suppressor gene encoding a protein with sequence similarity to cell adhesion molecules such as N-CAM. A set of overlapping YAC clones that contains the entire DCC coding region was isolated. Studies of this YAC contig showed that the DCC gene spans approximately 1.4 Mb. F...
Topics
- Amino Acid Sequence
- Base Sequence
- Chromosomes, Artificial, Yeast
- Chromosomes, Human, Pair 18
- Colorectal Neoplasms
- Consensus Sequence
- DNA Mutational Analysis
- DNA, Neoplasm
- Exons
- Genes, DCC
- Genetic Markers
- Humans
- Molecular Sequence Data
- Mutation
- Point Mutation
- Sequence Deletion