Article
The DCC gene: structural analysis and mutations in colorectal carcinomas.
Genomics - 1 Feb 1994
Cho K R, Oliner J D, Simons J W, Hedrick L, Fearon E R, Preisinger A C, Hedge P, Silverman G A, Vogelstein B
Abstract excerpt
DCC is a candidate tumor-suppressor gene encoding a protein with sequence similarity to cell adhesion molecules such as N-CAM. A set of overlapping YAC clones that contains the entire DCC coding region was isolated. Studies of this YAC contig showed that the DCC gene spans approximately 1.4 Mb. For elucidation of exon-intron structure, lambda phage clones containing all known coding sequences were isolated from a...
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