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Article

Analysis of the DCC tumor suppressor gene in testicular germ cell tumors: mutations and loss of expression.

The Journal of urology - 1 May 1997

Strohmeyer D, Langenhof S, Ackermann R, Hartmann M, Strohmeyer T, Schmidt B

Abstract excerpt

Inactivation of the DCC (Deleted in Colon Carcinoma) tumor suppressor gene by allelic loss and/or reduced expression is associated with the development of colon cancer, gliomas, gastric and prostatic malignancies. In a total cohort of 51 testicular germ cell tumors (GCT) of different histologies we analyzed restriction fragment length polymorphism (RFLP) for DCC at two specific DNA sites in 37 GCT and DCC mRNA...

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Source

Identifiers

PMID: 9112574

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the DCC tumor suppressor gene in testicular germ cell tumors: mutations and loss of expression.PMID 9112574Read ↗

Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors.Semantic proximity Read ↗

Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer.Semantic proximity Read ↗

The DCC gene suppresses the malignant phenotype of transformed human epithelial cells.Semantic proximity Read ↗

Frequent loss of expression and loss of heterozygosity of the putative tumor suppressor gene DCC in prostatic carcinomas.Semantic proximity Read ↗

DCC expression is altered by multiple mechanisms in brain tumours.Semantic proximity Read ↗

[Expression and loss of heterozygosity of DCC gene in human lung cancer].Semantic proximity Read ↗

[Loss of heterozygosity involving DCC gene in human colorectal cancers is correlated with the metastatic potential].Semantic proximity Read ↗

Role of the Dependence Receptor DCC in Colorectal Cancer PathogenesisSemantic proximity Read ↗

The DCC gene: structural analysis and mutations in colorectal carcinomas.Semantic proximity Read ↗

Somatic allelic loss at the DCC, APC, nm23-H1 and p53 tumor suppressor gene loci in human prostatic carcinoma.Semantic proximity Read ↗

Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene.Semantic proximity Read ↗

[Structure and function of DCC (deleted in colorectal cancer) gene and its product].Semantic proximity Read ↗

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