Codon 201(Gly) polymorphic type of the DCC gene is related to disseminated neuroblastoma.

doi:10.1038/sj.neo.7900169

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Article

Codon 201(Gly) polymorphic type of the DCC gene is related to disseminated neuroblastoma.

Neoplasia (New York, N.Y.) - 1 Jan 2000

Kong X T, Choi S H, Bessho F, Kobayashi M, Hanada R, Yamamoto K, Hayashi Y

Abstract excerpt

The deleted in colorectal carcinoma (DCC) gene is a potential tumor-suppressor gene on chromosome 18q21.3. The relatively high frequency of loss of heterozygosity (LOH) and loss of expression of this gene in neuroblastoma, especially in the advanced stages, imply the possibility of involvement of the DCC gene in progression of neuroblastoma. However, only few typical mutations have been identified in this gene,...

Topics

Adolescent
Cell Adhesion Molecules
Child
Child, Preschool
Codon
Colorectal Neoplasms
DCC Receptor
Exons
Female
Genes, DCC
Genes, Tumor Suppressor
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant

Infant, Newborn

Japan

Male

Mutation

Neoplasm Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 11571626
DOI: 10.1038/sj.neo.7900169
PMCID: PMC1505858

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