HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells.

doi:10.1038/368554a0

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HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells.

Nature - 7 Apr 1994

Fling S P, Arp B, Pious D

Abstract excerpt

Major histocompatibility complex (MHC) class II molecules are highly polymorphic cell-surface glycoproteins that present antigenic peptides to CD4+ T lymphocytes. The normal assembly of class II molecules with cognate peptides for antigen presentation requires an accessory function provided by a gene mapping to the class II region of the HLA complex. The isolation of somatic cell mutants of antigen-presenting...

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HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells.

Abstract excerpt

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HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells.

Abstract excerpt

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