Article
HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells.
Nature - 7 Apr 1994
Fling S P, Arp B, Pious D
Abstract excerpt
Major histocompatibility complex (MHC) class II molecules are highly polymorphic cell-surface glycoproteins that present antigenic peptides to CD4+ T lymphocytes. The normal assembly of class II molecules with cognate peptides for antigen presentation requires an accessory function provided by a gene mapping to the class II region of the HLA complex. The isolation of somatic cell mutants of antigen-presenting...
Topics
- Antigen-Presenting Cells
- Base Sequence
- Cells, Cultured
- DNA Primers
- DNA, Complementary
- HLA-D Antigens
- Histocompatibility Antigens Class II
- Humans
- Molecular Sequence Data
- Mutation
- Phenotype