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Article

Antigen presentation and assembly by mouse I-Ak class II molecules in human APC containing deleted or mutated HLA DM genes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1994

Brooks A G, Campbell P L, Reynolds P, Gautam A M, McCluskey J

Abstract excerpt

The behavior of mouse I-Ak molecules was studied in the human Ag presentation mutants T2 and 9.5.3, which contain deleted or mutated HLA DM genes. HLA class II molecules expressed by these APC are defective in presentation of native Ag and are mostly complexed with class II-associated invariant chain peptides (CLIP). In contrast to human class II molecules, a significant proportion of mouse I-Ak molecules...

Topics

Animals
Anti-Bacterial Agents
Antigen Presentation
Antigen-Presenting Cells
Cell Line
Flow Cytometry
HLA-D Antigens
Histocompatibility Antigens Class II
Humans
Immunoblotting
Macrolides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Precipitin Tests

Source

Identifiers

PMID: 7989744

Genes

APC
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7989744-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Antigen presentation and assembly by mouse I-Ak class II molecules in human APC containing deleted or mutated HLA DM genes.PMID 7989744Read ↗

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In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides.Semantic proximity Read ↗

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Impaired antigen presentation by murine I-Ad class II MHC molecules expressed in normal and HLA-DM-defective human B cell lines.Semantic proximity Read ↗

Posttranslational regulation of I-Ed by affinity for CLIP.Semantic proximity Read ↗

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