Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells.

doi:10.1016/1074-7613(94)90049-3

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Article

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells.

Immunity - 1 Oct 1994

Denzin L K, Robbins N F, Carboy-Newcomb C, Cresswell P

Abstract excerpt

MHC class II molecules expressed in T2 cells fail to acquire a normal complement of endocytically generated peptides. The defect is repaired by introducing HLA-DMA and HLA-DMB cDNA expression vectors, determined by the restoration of SDS stability of class II alpha beta dimers, restoration of a normal conformation for HLA-DR3 as detected by a monoclonal antibody, and by a reduction in class II-associated...

Topics

Antigen Presentation
Antigens, Differentiation, B-Lymphocyte
Base Sequence
Biological Transport
Cell Line
Cell Membrane
Flow Cytometry
HLA-D Antigens
HLA-DR3 Antigen
Histocompatibility Antigens Class II
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hybrid Cells

Kinetics

Molecular Sequence Data

Mutation

Neoplasm Proteins

Precipitin Tests

Sodium Dodecyl Sulfate

Source

Open in PubMed

Identifiers

PMID: 7600288
DOI: 10.1016/1074-7613(94)90049-3

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7600288-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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