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Article

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells.

Immunity - 1 Oct 1994

Denzin L K, Robbins N F, Carboy-Newcomb C, Cresswell P

Abstract excerpt

MHC class II molecules expressed in T2 cells fail to acquire a normal complement of endocytically generated peptides. The defect is repaired by introducing HLA-DMA and HLA-DMB cDNA expression vectors, determined by the restoration of SDS stability of class II alpha beta dimers, restoration of a normal conformation for HLA-DR3 as detected by a monoclonal antibody, and by a reduction in class II-associated...

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PMID: 7600288
DOI: 10.1016/1074-7613(94)90049-3

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SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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