Article
An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules.
Nature - 7 Apr 1994
Morris P, Shaman J, Attaya M, Amaya M, Goodman S, Bergman C, Monaco J J, Mellins E
Abstract excerpt
In antigen-presenting cells, class II molecules of the major histocompatibility complex (MHC) bind peptides derived from endocytosed proteins. In certain B-lymphoblastoid cell mutants, MHC class II molecule-peptide complex formation is impaired, resulting in deficient antigen-presenting function. MHC deletion mutants with this defect map the responsible gene(s) to the class II region of the MHC. Here we report...
Topics
- Animals
- Antigen-Presenting Cells
- B-Lymphocytes
- Base Sequence
- Cell Line
- HLA-D Antigens
- Histocompatibility Antigens Class II
- Humans
- Mice
- Molecular Sequence Data
- Mutation