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Article

Genetic complexity of regulatory mutants defective for HLA class II gene expression.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1992

Seidl C, Saraiya C, Osterweil Z, Fu Y P, Lee J S

Abstract excerpt

MHC (called HLA in man) class II genes play an essential role in cell-mediated immunity. Absence of HLA class II Ag on B lymphocytes is the basis of some congenital immunodeficiencies (CID). We have studied CID by generating transient heterokaryons from cell lines of such patients, and we report that the mutations fall into four complementation groups. In addition, fusions with the HLA class II deletion mutant...

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PMID: 1538137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Genetic complexity of regulatory mutants defective for HLA class II gene expression.PMID 1538137Read ↗

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