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Article

Genetic complexity of regulatory mutants defective for HLA class II gene expression.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1992

Seidl C, Saraiya C, Osterweil Z, Fu Y P, Lee J S

Abstract excerpt

MHC (called HLA in man) class II genes play an essential role in cell-mediated immunity. Absence of HLA class II Ag on B lymphocytes is the basis of some congenital immunodeficiencies (CID). We have studied CID by generating transient heterokaryons from cell lines of such patients, and we report...

Topics

Base Sequence
Cell Line
DNA-Binding Proteins
Genes, MHC Class II
Genetic Complementation Test
HLA-DQ Antigens
HLA-DR Antigens
Humans
Immunologic Deficiency Syndromes
Molecular Sequence Data
Mutation
Transcription, Genetic

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PMID: 1538137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1538137-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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