Article
Gene required for normal MHC class II expression and function is localized to approximately 45 kb of DNA in the class II region of the MHC.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1994
Ceman S, Petersen J W, Pinet V, DeMars R
Abstract excerpt
In certain mutant human B cell lines, MHC-encoded class II molecules displayed at the cell surface have an abnormal conformation and are unstable in the presence of SDS. The mutants cannot present exogenous protein Ags to T cells but elicit responses with exogenous antigenic peptides; thus, forma...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Amino Acid Transport Systems
- Carrier Proteins
- Chromosome Mapping
- Cysteine Endopeptidases
- DNA
- Exoribonucleases
- Fungal Proteins
- Gene Deletion
- Genes, MHC Class II
- HLA-DR Antigens
- Histocompatibility Antigens Class II
- Humans
- Multienzyme Complexes
- Mutation
- Proteasome Endopeptidase Complex
- Proteins