Article
An insertion mutant in DQA1*0501 restores susceptibility to HLA-DM: implications for disease associations.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2011
Hou Tieying, Macmillan Henriette, Chen Zhenjun, Keech Catherine L, Jin Xi, Sidney John, Strohman Michael, Yoon Taejin, Mellins Elizabeth D
Abstract excerpt
HLA-DM (DM) catalyzes CLIP release, stabilizes MHC class II molecules, and edits the peptide repertoire presented by class II. Impaired DM function may have profound effects on Ag presentation events in the thymus and periphery that are critical for maintenance of self-tolerance. The associations of the HLA-DQ2 (DQ2) allele with celiac disease and type 1 diabetes mellitus have been appreciated for a long time....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.