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Article

Mutant MHC class I molecules define interactions between components of the peptide-loading complex.

International immunology - 1 Apr 2002

Paquet Marie-Eve, Williams David B

Abstract excerpt

Class I histocompatibility molecules, consisting of a heavy chain, beta2-microglobulin and peptide, are assembled in the endoplasmic reticulum (ER) with the assistance of several molecular chaperones and accessory proteins. Peptide binding occurs when assembling class I molecules associate with a loading complex consisting of the transporter associated with antigen processing (TAP) peptide transporter, tapasin,...

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PMID: 11934871
DOI: 10.1093/intimm/14.4.347

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Research trail→

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Mutant MHC class I molecules define interactions between components of the peptide-loading complex.PMID 11934871Read ↗

Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.Semantic proximity Read ↗

Increased efficiency of folding and peptide loading of mutant MHC class I molecules.Semantic proximity Read ↗

Critical role for the tapasin-docking site of TAP2 in the functional integrity of the MHC class I-peptide-loading complex.Semantic proximity Read ↗

Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice.Semantic proximity Read ↗

Physical and functional association of the major histocompatibility complex class I heavy chain alpha3 domain with the transporter associated with antigen processing.Semantic proximity Read ↗

The cell biology of major histocompatibility complex class I assembly: towards a molecular understandingSemantic proximity Read ↗

Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.Semantic proximity Read ↗

Effect of a tapasin mutant on the assembly of the mouse MHC class I molecule H2-K(d).Semantic proximity Read ↗

Genetics of antigen processing and presentationSemantic proximity Read ↗

Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.Semantic proximity Read ↗

The redox activity of ERp57 is not essential for its functions in MHC class I peptide loading.Semantic proximity Read ↗

Gene required for normal MHC class II expression and function is localized to approximately 45 kb of DNA in the class II region of the MHC.Semantic proximity Read ↗

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