Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.

Abstract excerpt

Invariant chain (Ii) associates with class II MHC molecules and is crucial for Ag presentation by class II molecules. A general explanation for how invariant chain (Ii) associates with polymorphic MHC class II molecules has been suggested by the crystallographic structure of CLIP (class II-associ...

Topics

• Alanine
• Alleles
• Animals
• Antigen Presentation
• Antigens, Differentiation, B-Lymphocyte
• Histocompatibility Antigens Class II
• L Cells
• Methionine
• Mice
• Mutation
• Peptides