A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex.

doi:10.1084/jem.174.6.1607

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Article

A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex.

The Journal of experimental medicine - 1 Dec 1991

Mellins E, Kempin S, Smith L, Monji T, Pious D

Abstract excerpt

We have previously described a set of mutants (16.23-selected mutants) of a B lymphoblastoid cell line that are defective in the presentation of intact proteins to class II-restricted T cells, but effectively present immunogenic peptides. The mutations in these mutants are recessive in somatic ce...

Topics

Antigen-Presenting Cells
Antigens, Surface
Chromosome Deletion
Chromosome Mapping
Genes, MHC Class II
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Homozygote
Mutation
Phenotype

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