Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel mutants define genes required for the expression of human histocompatibility leukocyte antigen DM: evidence for loci on human chromosome 6p.

The Journal of experimental medicine - 3 Nov 1997

Fling S P, Rak J, Muczynski K A, Arp B, Pious D

Abstract excerpt

We and others have shown that the products of the HLA-DM locus are required for the intracellular assembly of major histocompatibility complex class II molecules with cognate peptides for antigen presentation. HLA-DM heterodimers mediate the dissociation of invariant chain (Ii)-derived class II-associated Ii peptides (CLIP) from class II molecules and facilitate the loading of class II molecules with antigenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Membrane

Share to Electrophoresis, Polyacrylamide Gel

Share to Gene Deletion

Share to Genetic Complementation Test

Share to Homozygote

Share to Mutagenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 9348304
DOI: 10.1084/jem.186.9.1469
PMCID: PMC2199108

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel mutants define genes required for the expression of human histocompatibility leukocyte antigen DM: evidence for loci on human chromosome 6p.PMID 9348304Read ↗

An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules.Semantic proximity Read ↗

Antigen presentation and T cell development in H2-M-deficient mice.Semantic proximity Read ↗

Antigen presentation and assembly by mouse I-Ak class II molecules in human APC containing deleted or mutated HLA DM genes.Semantic proximity Read ↗

HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells.Semantic proximity Read ↗

Human leukocyte Antigen-DM polymorphisms in autoimmune diseases.Semantic proximity Read ↗

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes.Semantic proximity Read ↗

DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms.Semantic proximity Read ↗

Gene required for normal MHC class II expression and function is localized to approximately 45 kb of DNA in the class II region of the MHC.Semantic proximity Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

Mutation at amino acid position 133 of H-2Dd prevents beta 2m association and immune recognition but not surface expression.Semantic proximity Read ↗

A minimum of four human class II alpha-chain genes are encoded in the HLA region of chromosome 6.Semantic proximity Read ↗

Analysis of HLA-DMB mutants and -DMB genomic structure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.