Article
Novel mutants define genes required for the expression of human histocompatibility leukocyte antigen DM: evidence for loci on human chromosome 6p.
The Journal of experimental medicine - 3 Nov 1997
Fling S P, Rak J, Muczynski K A, Arp B, Pious D
Abstract excerpt
We and others have shown that the products of the HLA-DM locus are required for the intracellular assembly of major histocompatibility complex class II molecules with cognate peptides for antigen presentation. HLA-DM heterodimers mediate the dissociation of invariant chain (Ii)-derived class II-associated Ii peptides (CLIP) from class II molecules and facilitate the loading of class II molecules with antigenic...
Topics
- Antibodies, Monoclonal
- Antigens, Differentiation, B-Lymphocyte
- B-Lymphocyte Subsets
- Cell Line, Transformed
- Cell Membrane
- Chromosomes, Human, Pair 6
- Dimerization
- Electrophoresis, Polyacrylamide Gel
- Gene Deletion
- Genes, MHC Class II
- Genetic Complementation Test
- HLA-D Antigens