Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.

The EMBO journal - 15 Mar 1994

Gottlieb E, Haffner R, von Rüden T, Wagner E F, Oren M

Abstract excerpt

Overexpression of wild-type p53 in p53-deficient leukemic cells induces apoptosis, which can be inhibited by hematopoietic survival factors. This suggests that p53 may contribute to survival factor dependence. To assess the role of wild-type p53 in mediating apoptosis following survival factor withdrawal, we interfered with endogenous p53 activity in interleukin-3 (IL-3)-dependent cells. Extended survival without...

Topics

Animals
Apoptosis
Bone Marrow
Bone Marrow Cells
Cells, Cultured
Down-Regulation
Hematopoietic Stem Cells
Interleukin-3
Mice
Mutation
Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 8137820
DOI: 10.1002/j.1460-2075.1994.tb06390.x
PMCID: PMC394954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8137820-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.PMID 8137820Read ↗

Anti-apoptotic activity of low levels of wild-type p53.Semantic proximity Read ↗

p53 restoration kills primitive leukemia cells in vivo and increases survival of leukemic mice.Semantic proximity Read ↗

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6.Semantic proximity Read ↗

Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potential and inhibits apoptosis.Semantic proximity Read ↗

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.Semantic proximity Read ↗

Delayed expression of apoptosis in X-irradiated human leukemic MOLT-4 cells transfected with mutant p53.Semantic proximity Read ↗

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).Semantic proximity Read ↗

Reconstitution of wild-type p53 expression triggers apoptosis in a p53-negative v-myc retrovirus-induced T-cell lymphoma line.Semantic proximity Read ↗

The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.Semantic proximity Read ↗

Regulation of p53-mediated apoptosis and cell cycle arrest by Steel factor.Semantic proximity Read ↗

Cytokine mediated suppression of TF-1 apoptosis requires PI3K activation and inhibition of Bim expression.Semantic proximity Read ↗

Characterization of the molecular mechanisms for p53-mediated differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.