Article
Characterization of the molecular mechanisms for p53-mediated differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Nov 2000
Chylicki K, Ehinger M, Svedberg H, Gullberg U
Abstract excerpt
The p53 tumor suppressor protein can induce both apoptosis and cell cycle arrest. Moreover, we and others have shown previously that p53 is a potent mediator of differentiation. For example, expression of ptsp53, a temperature-inducible form of p53, induces differentiation of leukemic monoblastic U-937 cells. The functions of p53 have for long been believed to be dependent on the transactivating capacity of p53....
Topics
- Apoptosis
- Cell Cycle
- Cell Differentiation
- Cell Division
- Cell Survival
- Cholecalciferol
- Clone Cells
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Flow Cytometry
- Gene Expression Regulation, Neoplastic
- Humans
- Integrin alphaXbeta2
- Kinetics